UPDATED PUBLICATIONS COMING SOON

In Press / Online Prepublication

2018

Cassidy C.M., Balsam P.D., Weinstein J.J., Rosengard R.J., Slifstein M., Daw N.D., Abi-Dargham A., Horga G. (2018). A Perceptual Inference Mechanism for Hallucinations Linked to Striatal Dopamine. Curr Biol. 28(4):503-514.

Kegeles L.S., Horga G., Ghazzaoui R., Rosengard R., Ojeil N., Xu X., Slifstein M., Petrakis I., O'Malley S.S., Krystal J.H., Abi-Dargham A. (2018). Enhanced Striatal Dopamine Release to Expectation of Alcohol: A Potential Risk Factor for Alcohol Use Disorder. Biol Psychiatry Cogn Neurosci Neuroimaging. 3(7):591-598.

Schneier F.R, Slifstein M., Whitton A.E., Pizzagalli D.A., Reinen J., McGrath P.J., Iosifescu D.V., Abi-Dargham A. (2018). Dopamine Release in Antidepressant-Naive Major Depressive Disorder: A Multimodal [11C]-(+)-PHNO Positron Emission Tomography and Functional Magnetic Resonance Imaging Study. Biol Psychiatry. [Epub ahead of print]

2017

Colibazzi T., Yang Z., Horga G., Chao-Gan Y., Corcoran C.M., Klahr K., Brucato G., Girgis R., Abi-Dargham A., Milham M.P., Peterson B.S. (2017). Aberrant Temporal Connectivity in Persons at Clinical High Risk for Psychosis. Biol Psychiatry Cogn Neurosci Neuroimaging. 2(8):696-705

Lehembre-Shiah E., Leong W., Brucato G., Abi-Dargham A., Lieberman J.A., Horga G., Girgis R.R. (2017). Distinct Relationships Between Visual and Auditory Perceptual Abnormalities and Conversion to Psychosis in a Clinical High-Risk Population. JAMA Psychiatry. 74(1):104-106.

Weinstein J.J., Van de Giessen E., Rosengard R.J., Xu X., Ojeil N., Brucato G., Gil R.B., Kegeles L.S., Laruelle M., Slifstein M., Abi-Dargham A. (2017). PET imaging of dopamine-D2 receptor internalization in schizophrenia. Mol Psychiatry. 

Van de Giessen E.*, Weinstein J.J.*, Cassidy C.M., Haney M., Dong Z., Ghazzaoui R., Ojeil N., Kegeles L.S., Xu X., Vadhan N.P., Volkow N.D., Slifstein M., Abi-Dargham A. (2017). Deficits in striatal dopamine release in cannabis dependence. Mol Psychiatry. 22(1):68-75. *These authors contributed equally to this work.

2016

Weinstein, J.J., Chohan, M. O., Slifstein, M., Kegeles, L., Moore, H., & Abi-Dargham, A. (2016). Pathway-specific dopamine abnormalities in schizophrenia. Biological Psychiatry, 81, 31-42.

Abi-Dargham, A., & Horga, G. (2016). The search for imaging biomarkers in psychiatric disorders. Nature Medicine22, 1248-1255.

Van Snellenberg, J. X., Girgis, R. R., Horga, G., van de Giessen, E., Slifstein, M., Ojeil, N., Weinstein, J., Moore, H., Lieberman, J., Shohamy, D., Smith, E. E., & Abi-Dargham, A. (2016). Mechanisms of Working Memory Impairment in Schizophrenia. Biological Psychiatry80, 617-626.

Horga, G., Cassidy, C.M., Xu, X., Moore, H., Slifstein, M., & Van Snellenberg, J.X.*, Abi-Dargham, A.* (2016). Dopamine-related disruption of functional topography of striatal connections in unmedicated patients with schizophrenia. JAMA Psychiatry, 73, 362-370. *These authors contributed equally to this work.

Cassidy, C., Van Snellenberg, J., Benavides, C., Slifstein, M., Wang, Z., Moore, H., Abi-Dargham A, & Horga, G. (2016). Dynamic connectivity between brain networks supports working memory: relationships to dopamine release and schizophrenia. Journal of Neuroscience36, 4377-4388.

Reinen, J. M., Van Snellenberg, J. X., Horga, G., Abi-Dargham, A., Daw, N. D., & Shohamy, D. (2016). Motivational context modulates prediction error response in schizophrenia. Schizophrenia Bulletin42, 1467-1475.

Girgis, R. R., Van Snellenberg, J.X., Glass, A., Kegeles, L.S., Thompson, J.L., Wall, M., Cho, R.Y., Carter, C.S., Slifstein, M., Abi-Dargham, A., & Lieberman, J.A. (2016). A proof-of-concept, randomized controlled trial of DAR-0100A, a dopamine-1 receptor agonist, for cognitive enhancement in schizophrenia. Journal of Psychopharmacology30, 428-435.

Roffman J.L., Tanner A.S., Eryilmaz H., Rodriguez-Thompson A., Silverstein N.J., Ho N.F., Nitenson A.Z., Chonde D.B., Greve D.N., Abi-Dargham A., Buckner R.L., Manoach D.S., Rosen B.R., Hooker J.M., Catana C. (2016) Dopamine D1 signaling organizes network dynamics underlying working memory. Sci Adv. 2(6):e1501672.

Wiers C.E., Shokri-Kojori E., Wong C.T., Abi-Dargham A., Demiral Ş.B., Tomasi D., Wang G.J., Volkow N.D.. (2016). Cannabis Abusers Show Hypofrontality and Blunted Brain Responses to a Stimulant Challenge in Females but not in Males. Neuropsychopharmacology. 41(10):2596-605.

2015

Slifstein, M.,* van de Giessen, E.,* Van Snellenberg, J., Thompson, J. L., Narendran, R., Gil, R., Hackett, E., Girgis, R., Ojeil, N., Moore, H., D’Souza, D., Malison, R. T., Huang, Y., Lim, K-P., Nabulsi, N., Carson, R.E., Lieberman, J.A., & Abi-Dargham, A. (2015). Deficits in prefrontal cortical and extra-striatal dopamine release in schizophrenia: a PET fMRI study. JAMA Psychiatry72, 316-324. *These authors contributed equally to this work.

Van Snellenberg, J.X., Slifstein, M., Read, C., Weber, J., Thompson, J. L., Wager, T. D., Shohamy, D., Abi-Dargham, A., & Smith, E. E. (2015). Dynamic shifts in brain network activation during supracapacity working memory task performance. Hum Brain Mapping36, 1245-1264.

Girgis, R.R., Xu, X., Gil, R.B., Hackett, E., Ojeil, N., Lieberman, J.A., Slifstein, M., & Abi-Dargham, A. (2015). Antipsychotic binding to the dopamine-3 receptor in humans: A PET study with [11C]-(+)-PHNO. Schizophrenia Research168, 373-376.

Weinstein, J.J., Rogers, B.P., Taylor, W.D., Boyd, B.D., Cowan, R.L., Shelton, K.M., & Salomon, R.M. (2015). Effects of acute tryptophan depletion on raphé functional connectivity in depression. Psychiatry Research234, 164-171.

Rosell, D.R., Zaluda, L.C., McClure, M.M., Perez-Rodriguez, M.M., Strike, K.S., Barch, D.M., Harvey, P.D., Girgis, R.R., Hazlett, E.A., Mailman, R.B., Abi-Dargham, A., Lieberman, J.A., & Siever, L.J. (2015). Effects of the D1 dopamine receptor agonist dihydrexidine (DAR-0100A) on working memory in schizotypal personality disorder. Neuropsychopharmacology40, 446-453.

Corbin, W.R., Papova, A., Morean, M.E., O'Malley, S.S., Krishnan-Sarin, S., Abi-Dargham, A., Anticevic, A., Pearlson, G., Petrakis, I., Pittman, B.P., & Krystal, J.H. (2015). Integrating acquired preparedness and dual process models of risk for heavy drinking and related problems. Psychology of Addictive Behaviors29, 864-874.

Colibazzi, T., Horga, G., Wang, Z., Huo, Y., Corcoran, C., Klahr, K., Brucato, G., Girgis, R., Gill, K., Abi-Dargham, A., & Peterson, B.S. Neural Dysfunction in Cognitive Control Circuits in Persons at Clinical High-Risk for Psychosis. Neuropsychopharmacology41, 1241-1250.

2014

Horga, G., Schatz, K.C., Abi-Dargham, A., & Peterson, B.S. (2014). Deficits in predictive coding underlie hallucinations in schizophrenia. The Journal of Neuroscience, 34, 8072-8082.

Van Snellenberg, J.X., Conway, A.R.A., Spicer, J., Read, C., & Smith, E.E. (2014). Capacity estimates in working memory: Reliability and interrelationships among tasks. Cognitive, Affective, and Behavioral Neuroscience14, 106-116.

Kambeitz, J., Abi-Dargham, A., Kapur, S., & Howes, O.D. (2014). Alterations in cortical and extrastriatal subcortical dopamine function in schizophrenia: systematic review and meta-analysis of imaging studies. British Journal of Psychiatry, 204, 420-429.

Thompson, J.L., Rosell, D.R., Slifstein, M., Girgis, R.R., Xu, X., Ehrlich, Y., Kegeles, L.S., Hazlett, E.A., Abi-Dargham, A., & Siever, L.J. (2014). Prefrontal dopamine D1 receptors and working memory in schizotypal personality disorder: a PET study with [¹¹C]NNC112. Psychopharmacology231, 4231-4240.

Hwang, D.R., Hu, E., Rumfelt, S., Easwaramoorthy, B., Castrillon, J., Davis, C., Allen, J.R., Chen, H., Treanor, J., Abi-Dargham, A., & Slifstein M. (2014). Initial characterization of a PDE10A selective positron emission tomography tracer [11C]AMG 7980 in non-human primates. Nuclear Medicine and Biology41, 343-349.

Chen, C.M., Stanford, A.D., Mao, X., Abi-Dargham, A., Shungu, D.C., Lisanby, S.H., Schroeder, C.E., & Kegeles, L.S. GABA level, gamma oscillation, and working memory performance in schizophrenia. NeuroImage: Clinical20, 531-539.

Ridler, K., Cunningham, V., Huiban, M., Martarello, L., Pampols-Maso, S., Passchier, J., Gunn, R. N., Searle, G., Abi-Dargham, A., Slifstein, M., Watson, J., Laruelle, M., & Rabiner, E.A. (2014). An evaluation of the brain distribution of [11C]GSK1034702, a muscarinic-1 (M1) positive allosteric modulator in the living human brain using positron emission tomography, EJNMMI Research4, 66.

van de Giessen, E., Rosell, D.R., Thompson, J.L., Xu, X., Girgis, R.R., Ehrlich, Y., Slifstein, M., Abi-Dargham, A., & Siever, L.J. (2014). Serotonin transporter availability in impulsive aggressive personality disordered patients: a PET study with [11C]DASB. Journal of Psychiatric Research58, 147-154.

2013

Thompson, J.L., Urban, N., Slifstein, M., Xu, X., Kegeles, L.S., Girgis, R.R., Beckerman, Y., Harkavy-Friedman, J.M., Gil, R., & Abi-Dargham, A. (2013). Blunted Striatal Dopamine Release in Schizophrenia Comorbid with Substance Dependence, Molecular Psychiatry18, 909-915

Poels, E.M., Girgis, R.R., Thompson, J.L., Slifstein, M., & Abi-Dargham, A. (2013). In vivo binding of the dopamine-1 receptor PET tracers [11C]NNC112 and [ 11C]SCH23390: a comparison study in individuals with schizophrenia. Psychopharmacology228, 167-174.

2012

Talbot, P.S., Slifstein, M., Hwang, D.-R., Huang, Y., Scher, E., Abi-Dargham, A., & Laruelle, M. (2012). Extended characterisation of the serotonin 2A (5-HT2A) receptor-selective PET radiotracer 11C-MDL100907 in humans: Quantitative analysis, test-retest reproducibility, and vulnerability to endogenous 5-HT tone. NeuroImage59, 271-285.

Kegeles, L.S., Mao, X., Stanford, A. D., Girgis, R., Ojeil, N., Xu, X., Gil, R., Abi-Dargham, A., Lisanby, S.H., & Shungu, D. C. (2012). Elevated Prefrontal Cortex g-Aminobutryic Acid and Glutamate-Glutamine Levels in Schizophrenia Measured In Vivo with Proton Magnetic Resonance Spectroscopy, Archives of Gen Psychiatry69, 449-459.

Urban, N.B.L., Slifstein, M., Meda, S., Xu, X., Ayoub, R., Medina, O., Pearlson G.D., Krystal, J.H., & Abi-Dargham, A. (2012). Imaging human reward processing with positron emission tomography and functional magnetic resonance imaging. Psychopharmacology221, 67-77.

Urban, N., Slifstein, M., Thompson, J., Xu, X., Girgis, R., Raheja, S., Haney, M, & Abi-Dargham, A. (2012). Dopamine release in cannabis dependence: a [11C]raclopride Positron Emission Tomography study. Biological Psychiatry, 71, 677-683.

Urban, N.B.L., Girgis, R.R., Talbot, P., Kegeles, L.S., Xu, X., Frankle, W.G., Slifstein, M., Abi-Dargham, A., & Laruelle, M. (2012). Sustained recreational use of ecstasy is associated with altered pre and postsynaptic markers of serotonin transmission in neocortical areas: a PET study with [11C]DASB and [11C]MDL 100907. Neuropsychopharmacology, 37, 1465-1473.

Broft, A., Shingleton, R., Kaufman, J., Liu, F., Kumar, D., Slifstein, M., Abi-Dargham, A., Schebendach, J., Van Heertum, R., Attia, E., Martinez, D., & Walsh, B.T. (2012). Striatal dopamine in bulimia nervosa: A pet imaging study. International Journal of Eating Disorders45, 648-656.

Howes, O.D., Kambeitz, J., Kim, E., Stahl, D., Slifstein, M., Abi-Dargham, A., & Kapur, S. (2012). The Nature of Dopamine Dysfunction in Schizophrenia and What This Means for Treatment: Meta-analysis of Imaging Studies. Archives of General Psychiatry69, 776-786

Abi-Dargham, A., Xu, X., Thompson, J.L., Gil, R., Kegeles, L.S., Urban, N., Narendran, R., Hwang, D-R., Laruelle, M., & Slifstein, M. (2012). Increased Prefrontal Cortical D1 receptors in drug naïve patients with schizophrenia: a PET study with [11C] NNC112. Journal of Psychopharmacology26, 794-805

2011

H. B Simpson, M Slifstein, J Bender Jr., X Xu, E Hackett, M J. Maher, A Abi-Dargham Serotonin 2A Receptors in Obsessive-Compulsive Disorder: a Positron Emission Tomography Study with [11C]MDL 100907, Biol Psychiatry, 2011 Nov 1;70(9):897-904

Girgis, R.R., Slifstein, M., Frankle, W.G., Anagnostou, E., Wasserman, S., Pepa, L., Kolevzon, A., Abi-Dargham, A., Laruelle, M., & Hollander, E. (2011). The 5HT-2A receptor and serotonin transporter in Asperger’s Disorder: a PET study with [11C] MDL and [11C] DASB. Psychiatry Research: Neuroimaging, 194, 230-234.

K Ridler, C Plisson, EA Rabiner, RN Gunn, B Easwaramoorthy, A Abi-Dargham, M Laruelle, M Slifstein,  Characterisation of in vivo pharmacological properties and sensitivity to endogenous serotonin of [11C]P943: a positron emission tomography study in Papio Anubis. Synapse, 2011 Nov; 65(11):1119-27.

Miyake N, Skinbjerg M, Easwaramoorthy B, Kumar D, Girgis RR, Xu X, Slifstein M, Abi-Dargham A. Imaging Changes in Glutamate Transmission In Vivo with the Metabotropic Glutamate Receptor 5 Tracer [(11)C] ABP688 and N-Acetylcysteine Challenge. Biol Psychiatry 2011 May 1;69(9):822-4

Girgis RR, Xu X, Miyake N, Easwaramoorthy B, Gunn RN, Rabiner EA, Abi-Dargham A, Slifstein. In Vivo Binding of Antipsychotics to D(3) and D(2) Receptors: A PET Study in Baboons with [(11)C]-(+)-PHNO. Neuropsychopharmacology. 36(4):887-95.

Slifstein M, Suckow RF, Javitch JA, Cooper T, Lieberman J, Abi-Dargham A. Characterization of in vivo pharmacokinetic properties of the dopamine D1 receptor agonist DAR-0100A in nonhuman primates using PET with [(11)C] NNC112 and [(11)C] raclopride. J Cereb Blood Flow Metab. J Cereb Blood Flow Metab. 2011 Jan;31(1):293-304

2010

Frankle WG, Lombardo I, Kegeles LS, Slifstein M, Martin JH, Huang Y, Hwang DR, Reich E, Cangiano C, Gil R, Abi-Dargham A, Laruelle M. Measurement of the serotonin 1A receptor availability in patients with schizophrenia during treatment with the antipsychotic medication ziprasidone. J Psychopharmacol. 2010, 25(6):734-43.

Rosell DR, Thompson JL, Slifstein M, Xu X, Frankle WG, New AS, Goodman M, Weinstein SR, Laruelle M, Abi-Dargham A, Siever LJ: Increased serotonin 2A receptor availability in the orbitofrontal cortex of physically aggressive personality disordered patients. Biol Psychiatry. 2010 Jun 15;67(12):1154-62

LS. Kegeles, M Slifstein, X Xu, N Urban, E Hackett, E Meyers, B Alvarez, R Gil, M Laruelle, A Abi-Dargham: Striatal and extrastriatal dopamine D2/D3 receptors in schizophrenia evaluated with [18F]fallypride PETBiol Psychiatry. 2010 Oct 1;68(7):634-41

Nina Urban MD, Lawrence S. Kegeles MD, Mark Slifstein PhD, Xiaoyan Xu PhD, Diana Martinez MD, Felipe Castillo, Stephanie O Malley PhD, John H. Krystal MD, Anissa Abi-Dargham MD: Striatal dopamine release in young adults after oral alcohol challenge: a PET imaging study with [11C]raclopride, Biol Psychiatry. 2010 Oct 15;68(8):689-96.

L S. Kegeles, MD, PhD, A Abi-Dargham, MD, W. G Frankle, MD, R Gil, MD, TB. Cooper, MA, M Slifstein, PhD, DR Hwang, PhD, Y Huang, PhD, S N. Haber, PhD, and M Laruelle, MD, Increased synaptic dopamine in associative rather than limbic regions of the striatum in schizophrenia, Archives of Gen Psychiatry, 2010 Mar; 67(3):231-9.

Mark Slifstein, Lawrence S. Kegeles, Xiaoyan Xu, Judy L. Thompson, Nina Urban, John Castrillon, Elizabeth Hackett, Sung-A Bae, Marc Laruelle and Anissa Abi-Dargham: Striatal and extrastriatal dopamine release measured with PET and [18F]Fallypride, Synapse. 2010 May; 64(5):350-62

N Guo, X, W Guo, M Jiang, I Schieren, R Narendran, M Slifstein, A Abi-Dargham, J A Javitch, M Laruelle, S Rayport: Impact of D2 receptor internalization on binding affinity of PET radiotracers, Neuropsychopharmacology, 2010 Feb;35(3):806-17

2009

Martinez, D. G. Frankle. Slifstein, D.R. Hwang, J. Martin, M. Laruelle, A. Abi-Dargham, Imaging serotonergic transmission in recently detoxified alcoholics and healthy controls using [11C]WAY-100635 and [11C]DASB. 2009 Jan 15;65(2):175-80Biol Psychiatry.

Schneier FR, Abi-Dargham A, Martinez D, Slifstein M, Hwang DR, Liebowitz MR, Laruelle M.: Dopamine transporters, D(2) receptors, and dopamine release in generalized social anxiety disorder.
Depress Anxiety. 2009 Jan 29. 2009;26(5):411-8

Martinez D, Slifstein M, Narendran R, Foltin RW, Broft A, Hwang DR, Perez A, Abi-Dargham A, Fischman MW, Kleber HD, Laruelle M.: Dopamine D1 Receptors in Cocaine Dependence Measured with PET and the Choice to Self-Administer Cocaine. Neuropsychopharmacology. 2009 Jun;34(7):1774-82

Abi-Dargham A, Giessen EV, Slifstein M, Kegeles LS, Laruelle M.: Baseline and Amphetamine-Stimulated Dopamine Activity Are Related in Drug-Naïve Schizophrenic Subjects., Biol Psychiatry. 2009 Jun 15;65(12):1091-3

Everett BA, Oquendo MA, Abi-Dargham A, Nobler MS, Devanand DP, Lisanby SH, Mann JJ, Parsey RV.  Safety of radial arterial catheterizations in PET research subjects, J Nucl Med. 2009 Oct; 50(10):1742

2008

Schneier FR, Martinez D, Abi-Dargham A, Zea-Ponce Y, Simpson HB, Liebowitz MR, Laruelle M.  Striatal dopamine D(2) receptor availability in OCD with and without comorbid social anxiety disorder: preliminary findings, Depress Anxiety. 2008;25(1):1-7.

M Slifstein, B Kolachana, E H. Simpson, P Tabares, B Cheng, M Duvall, G Frankle, D R. Weinberger, M Laruelle and A Abi-Dargham: COMT genotype predicts cortical-limbic D1 receptor availability measured with [11C] NNC112 and PET, Molecular Psychiatry, 2008, 13(8):821-7.

Kegeles LS, Slifstein M, Frankle WG, Xu X, Hackett E, Bae SA, Gonzales R, Kim JH, Alvarez B, Gil R, Laruelle M, A. Abi-Dargham: Occupancy of striatal and extrastriatal D2 by aripiprazole, and [18F]fallypride study, Neuropsychopharmacology, 2008 Dec;33(13):3111-25

2007

Mark Slifstein, Larry Kegeles, Robyn Gonzales, WG Frankle, Xiaoyan Xu, Marc Laruelle, Anissa Abi-Dargham: [11C] NNC 112 selectivity for dopamine D1 and serotonin 5HT2A receptors:  a PET study in healthy human subjects, JCBF, 2007;27(10):1733-41.

Jesper Ekelund, Mark Slifstein, Raj Narendran, Olivier Guillin, Hemant Belani, Ning-Ning Guo , Yuying Hwang, Dah-Ren Hwang, Anissa Abi-Dargham, Marc Laruelle,  In Vivo DA D1 Receptor Selectivity of NNC 112 and SCH 23390, Molecular Imaging and Biology, 2007, 9(3):117-25

Buchanan RW, Freedman R, Javitt DC, Abi-Dargham A, Lieberman JA. Recent advances in the development of novel pharmacological agents for the treatment of cognitive impairments in schizophrenia, Schizophr Bull. 2007, 33 (5): 1120-30

Seminal / Classic Work

Laruelle, M, Abi-Dargham, A., van Dyck, C. H., Gil, R., D'Souza, C. D., Erdos, J., McCance, E., Rosenblatt, W., Fingado, C., Zoghbi, S. S., Baldwin, R. M., Seibyl, J. P., Krystal, J. H., Charney, D. S., & Innis, R. B. (1996). Single photon emission computerized tomography imaging of amphetamine-induced dopamine release in drug free schizophrenic subjects. Proceedings of the National Academy of Sciences of the USA93, 9235-9240.

Abi-Dargham, A., Gil, R., Krystal, J., Baldwin, R. M., Seibyl, J. P., Bowers, M., van Dyck, C. H., Charney, D. S., Innis, R. B., & Laruelle, M. (1998). Increased striatal dopamine transmission in schizophrenia: Confirmation in a second cohort. American Journal of Psychiatry155, 761-767.

Abi-Dargham, A., Rodenhiser, J., Printz, D., Zea-Ponce, Y., Gil, R., Kegeles, L. S., Weiss, R., Cooper, T. B., Mann, J. J., Van Heertum, R. L., Gorman, J. M., & Laruelle, M (2000). Proceedings of the National Academy of Sciences of the USA97, 8104-8109.